International Journal of Innovative Approaches in Science Research
Abbreviation: IJIASR | ISSN (Print): 2602-4810 | ISSN (Online): 2602-4535 | DOI: 10.29329/ijiasr

Original article    |    Open Access
International Journal of Innovative Approaches in Science Research 2020, Vol. 4(3) 52-65

Investigation of the Synthesis and Biological Activity of A New Imine  Compound Containing Ferrocene and Benzothiazol

Büşra Dalgıç, Neslihan Demir & Mustafa Yıldız

pp. 52 - 65   |  DOI: https://doi.org/10.29329/ijiasr.2020.273.1

Published online: September 29, 2020  |   Number of Views: 272  |  Number of Download: 640

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Abstract

In this study, a new Schiff base containing ferrocene and benzothiazol was synthesized from the reaction of ferrocene-2-carboxialdehyde and 6-methoxybenzo[d]thiazole-2-amine. The structure of the synthesized original imine compound 2-((6-methoxybenzo[d]thiazol-2-ylimino)methyl) ferrocene was illuminated by UV-VIS, FTIR, MS and NMR spectroscopy. The antimicrobial activity of the compound was determined by the minimum inhibition concentration (MIC) method against various bacterial and yeast cultures, and the antioxidant activity was determined by the free radical scavenging activity of 2,2-diphenyl-1-picrilhydrazyl (DPPH). DNA cleavage activity of Schiff base was investigated hydrolytically and oxidatively by agarose gel electrophoresis method, and binding to DNA was investigated by UV-Visible field spectroscopy method. It was found that the studied ferrocene and benzothiazole imine compound had more effect on Pseudomonas aeruginosa (ATCC 27853) and Bacillus subtilis (ATCC 6633) bacteria. The compound was found to exhibit good antioxidant activity compared to the standardized butylated hydroxy toluene (BHT). Agarose gel electrophoresis studies showed that the compound cleaved DNA without any external agent, and UV-Vis spectroscopy studies showed that it interacted electrostatically with CT-DNA.

Keywords: Ferrocene-2-carboxyaldehyde, Benzothiazol, Schiff base, Antimicrobial activity, Antioxidant activity, DNA cleavage, DNA binding

How to Cite this Article

APA 6th edition
Dalgic, B., Demir, N. & Yildiz, M. (2020). Investigation of the Synthesis and Biological Activity of A New Imine  Compound Containing Ferrocene and Benzothiazol . International Journal of Innovative Approaches in Science Research, 4(3), 52-65. doi: 10.29329/ijiasr.2020.273.1

Harvard
Dalgic, B., Demir, N. and Yildiz, M. (2020). Investigation of the Synthesis and Biological Activity of A New Imine  Compound Containing Ferrocene and Benzothiazol . International Journal of Innovative Approaches in Science Research, 4(3), pp. 52-65.

Chicago 16th edition
Dalgic, Busra, Neslihan Demir and Mustafa Yildiz (2020). "Investigation of the Synthesis and Biological Activity of A New Imine  Compound Containing Ferrocene and Benzothiazol ". International Journal of Innovative Approaches in Science Research 4 (3):52-65. doi:10.29329/ijiasr.2020.273.1.
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