Pen Academic Publishing   |  ISSN: 2602-4810   |  e-ISSN: 2602-4535

Original article | International Journal of Innovative Approaches in Science Research 2018, Vol. 2(4) 140-151

Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis

Betül Özbek İpteç, Gamze Avcıoğlu, Ömer Faruk Şendur & Leyla Didem Kozacı

pp. 140 - 151   |  DOI:   |  Manu. Number: MANU-1811-22-0002

Published online: December 26, 2018  |   Number of Views: 42  |  Number of Download: 200


Background: Reactive oxygen species have a role in pathogenesis of osteoarthritis.

The main objective of this study was to determine other oxidant/antioxidant substances and inflammatory markers in hand osteoarthritis patients.

Methods: Thirty healthy controls and 50 patients with hand osteoarthritis (HOA) were included in the study. All patients were questioned about age, sex, history of the symptoms, presence of sensitive and swollen joints, smoking habits, other systemic diseases and medications. Serum thiol-disulfide homeostasis tests (TDHT), catalase (CAT), ceruloplasmin (Cp), arylesterase (ARES), paraoxonase (PON), stimulated paraoxonase (SPON), total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), myeloperoxidase (MPO), routine biochemistry tests and inflammatory markers: Interleukin-1b (IL-1b), interleukin-6 (IL-6), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured.

Results: MPO, TDHT, MDA, MPO and inflammatory markers (IL-6, CRP and ESR) were significantly different in HOA patients from those in control group (p=0.005; p=0.001; p=0.014; p=0.005; p=0.012; p=0.003 and p<0.001, respectively).

Conclusion: Our results support that oxidative stress increases in HOA and with the severity of the disease, suggesting that oxidative stress might be involved in pathogenesis of HOA.

Keywords: Oxidative stress, Thiol disulfide homeosthasis, Osteoarthritis, Erosive hand osteoarthritis, Non-erosive hand osteoarthritis, Inflammatory markers, Cytokines

How to Cite this Article?

APA 6th edition
Iptec, B.O., Avcioglu, G., Sendur, O.F. & Kozaci, L.D. (2018). Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis . International Journal of Innovative Approaches in Science Research, 2(4), 140-151. doi: 10.29329/ijiasr.2018.173.3

Iptec, B., Avcioglu, G., Sendur, O. and Kozaci, L. (2018). Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis . International Journal of Innovative Approaches in Science Research, 2(4), pp. 140-151.

Chicago 16th edition
Iptec, Betul Ozbek, Gamze Avcioglu, Omer Faruk Sendur and Leyla Didem Kozaci (2018). "Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis ". International Journal of Innovative Approaches in Science Research 2 (4):140-151. doi:10.29329/ijiasr.2018.173.3.

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