International Journal of Innovative Approaches in Science Research
Abbreviation: IJIASR | ISSN (Print): 2602-4810 | ISSN (Online): 2602-4535 | DOI: 10.29329/ijiasr

Original article    |    Open Access
International Journal of Innovative Approaches in Science Research 2018, Vol. 2(4) 140-151

Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis

Betül Özbek İpteç, Gamze Avcıoğlu, Ömer Faruk Şendur & Leyla Didem Kozacı

pp. 140 - 151   |  DOI: https://doi.org/10.29329/ijiasr.2018.173.3

Published online: December 26, 2018  |   Number of Views: 139  |  Number of Download: 650

Download PDF

Abstract

Background: Reactive oxygen species have a role in pathogenesis of osteoarthritis.

The main objective of this study was to determine other oxidant/antioxidant substances and inflammatory markers in hand osteoarthritis patients.

Methods: Thirty healthy controls and 50 patients with hand osteoarthritis (HOA) were included in the study. All patients were questioned about age, sex, history of the symptoms, presence of sensitive and swollen joints, smoking habits, other systemic diseases and medications. Serum thiol-disulfide homeostasis tests (TDHT), catalase (CAT), ceruloplasmin (Cp), arylesterase (ARES), paraoxonase (PON), stimulated paraoxonase (SPON), total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), myeloperoxidase (MPO), routine biochemistry tests and inflammatory markers: Interleukin-1b (IL-1b), interleukin-6 (IL-6), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured.

Results: MPO, TDHT, MDA, MPO and inflammatory markers (IL-6, CRP and ESR) were significantly different in HOA patients from those in control group (p=0.005; p=0.001; p=0.014; p=0.005; p=0.012; p=0.003 and p<0.001, respectively).

Conclusion: Our results support that oxidative stress increases in HOA and with the severity of the disease, suggesting that oxidative stress might be involved in pathogenesis of HOA.

Keywords: Oxidative stress, Thiol disulfide homeosthasis, Osteoarthritis, Erosive hand osteoarthritis, Non-erosive hand osteoarthritis, Inflammatory markers, Cytokines

How to Cite this Article

APA 6th edition
Iptec, B.O., Avcioglu, G., Sendur, O.F. & Kozaci, L.D. (2018). Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis . International Journal of Innovative Approaches in Science Research, 2(4), 140-151. doi: 10.29329/ijiasr.2018.173.3

Harvard
Iptec, B., Avcioglu, G., Sendur, O. and Kozaci, L. (2018). Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis . International Journal of Innovative Approaches in Science Research, 2(4), pp. 140-151.

Chicago 16th edition
Iptec, Betul Ozbek, Gamze Avcioglu, Omer Faruk Sendur and Leyla Didem Kozaci (2018). "Impaired Dynamic Thiol/disulfide Homeostasis and Pro-inflammatory Parameters in Hand Osteoarthritis ". International Journal of Innovative Approaches in Science Research 2 (4):140-151. doi:10.29329/ijiasr.2018.173.3.
References
  1. Lennerova T, Pavelka K, Senolt L. Biomarkers of hand osteoarthritis. Rheumatology international. 2018;38(5):725-35. [Google Scholar]
  2. Ramonda R, Lorenzin M, Modesti V, Campana C, Ortolan A, Frallonardo P, et al. Serological markers of erosive hand osteoarthritis. European journal of internal medicine. 2013;24(1):11-5. [Google Scholar]
  3. Saviola G, Abdi-Ali L, Povino MR, Campostrini L, Sacco S, Carbonare LD. Intramuscular clodronate in erosive osteoarthritis of the hand is effective on pain and reduces serum COMP: a randomized pilot trial-The ER.O.D.E. study (ERosive Osteoarthritis and Disodium-clodronate Evaluation). Clin Rheumatol. 2017;36(10):2343-50. [Google Scholar]
  4. Haugen IK, Mathiessen A, Slatkowsky-Christensen B, Magnusson K, Boyesen P, Sesseng S, et al. Synovitis and radiographic progression in non-erosive and erosive hand osteoarthritis: is erosive hand osteoarthritis a separate inflammatory phenotype? Osteoarthritis and cartilage. 2016;24(4):647-54. [Google Scholar]
  5. Marshall M, Nicholls E, Kwok WY, Peat G, Kloppenburg M, van der Windt D, et al. Erosive osteoarthritis: a more severe form of radiographic hand osteoarthritis rather than a distinct entity? Ann Rheum Dis. 2015;74(1):136-41. [Google Scholar]
  6. Dolzani P, Assirelli E, Pulsatelli L, Addimanda O, Mancarella L, Peri G, et al. Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis. Clin Exp Rheumatol. 2011;29(6):1006-9. [Google Scholar]
  7. Vlychou M, Koutroumpas A, Alexiou I, Fezoulidis I, Sakkas LI. High-resolution ultrasonography and 3.0 T magnetic resonance imaging in erosive and nodal hand osteoarthritis: high frequency of erosions in nodal osteoarthritis. Clin Rheumatol. 2013;32(6):755-62. [Google Scholar]
  8. Aborehab NM, El Bishbishy MH, Refaiy A, Waly NE. A putative Chondroprotective role for IL-1beta and MPO in herbal treatment of experimental osteoarthritis. BMC complementary and alternative medicine. 2017;17(1):495. [Google Scholar]
  9. Stern AG, de Carvalho MR, Buck GA, Adler RA, Rao TP, Disler D, et al. Association of erosive hand osteoarthritis with a single nucleotide polymorphism on the gene encoding interleukin-1 beta. Osteoarthritis and cartilage. 2003;11(6):394-402. [Google Scholar]
  10. Zamli Z, Sharif M. Chondrocyte apoptosis: a cause or consequence of osteoarthritis? Int J Rheum Dis. 2011;14(2):159-66. [Google Scholar]
  11. Zhuang C, Wang Y, Zhang Y, Xu N. Oxidative stress in osteoarthritis and antioxidant effect of polysaccharide from angelica sinensis. International journal of biological macromolecules. 2018;115:281-6. [Google Scholar]
  12. Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta radiologica: diagnosis. 1977;18(4):481-91. [Google Scholar]
  13. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem. 2014;47(18):326-32. [Google Scholar]
  14. Erel O. Automated measurement of serum ferroxidase activity. Clinical chemistry. 1998;44(11):2313-9. [Google Scholar]
  15. Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clinica chimica acta; international journal of clinical chemistry. 1991;196(2-3):143-51. [Google Scholar]
  16. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. The Journal of investigative dermatology. 1982;78(3):206-9. [Google Scholar]
  17. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277-85. [Google Scholar]
  18. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-11. [Google Scholar]
  19. Eckerson HW, Wyte CM, La Du BN. The human serum paraoxonase/arylesterase polymorphism. American journal of human genetics. 1983;35(6):1126-38. [Google Scholar]
  20. Haagen L, Brock A. A new automated method for phenotyping arylesterase (EC 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 1992;30(7):391-5. [Google Scholar]
  21. Asakawa T, Matsushita S. Coloring conditions of thiobarbituric acid test for detecting lipid hydroperoxides. Lipids. 1980;15(3):137-40. [Google Scholar]
  22. Silvestri T, Pulsatelli L, Dolzani P, Punzi L, Meliconi R. Analysis of cartilage biomarkers in erosive and non-erosive osteoarthritis of the hands. Osteoarthritis and cartilage. 2004;12(10):843-5. [Google Scholar]
  23. Olejarova M, Kupka K, Pavelka K, Gatterova J, Stolfa J. Comparison of clinical, laboratory, radiographic, and scintigraphic findings in erosive and nonerosive hand osteoarthritis. Results of a two-year study. Joint, bone, spine : revue du rhumatisme. 2000;67(2):107-12. [Google Scholar]
  24. Pantsulaia I, Kalichman L, Kobyliansky E. Association between radiographic hand osteoarthritis and RANKL, OPG and inflammatory markers. Osteoarthritis and cartilage. 2010;18(11):1448-53. [Google Scholar]
  25. Punzi L, Calo L, Plebani M. Clinical significance of cytokine determination in synovial fluid. Critical reviews in clinical laboratory sciences. 2002;39(1):63-88. [Google Scholar]
  26. Cai H, Sun HJ, Wang YH, Zhang Z. Relationships of common polymorphisms in IL-6, IL-1A, and IL-1B genes with susceptibility to osteoarthritis: a meta-analysis. Clin Rheumatol. 2015;34(8):1443-53. [Google Scholar]
  27. van den Berg WB. Arguments for interleukin 1 as a target in chronic arthritis. Ann Rheum Dis. 2000;59 Suppl 1:i81-4. [Google Scholar]
  28. Goldring SR, Goldring MB. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clinical orthopaedics and related research. 2004(427 Suppl):S27-36. [Google Scholar]
  29. Aderka D, Le JM, Vilcek J. IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. Journal of immunology (Baltimore, Md : 1950). 1989;143(11):3517-23. [Google Scholar]
  30. Roux CH, Foltz V, Maheu E, Baron G, Gandjbakhch F, Lukas C, et al. MRI and serum biomarkers correlate with radiographic features in painful hand osteoarthritis. Clin Exp Rheumatol. 2016;34(6):991-8. [Google Scholar]
  31. Oliviero F, Ramonda R, Punzi L. New horizons in osteoarthritis. Swiss Med Wkly. 2010;140:w13098. [Google Scholar]
  32. Sun C, Zhang S, Wei L, Zhang JZ. Clinical research on correction of ankle arthritis-related factor levels via urea. Eur Rev Med Pharmacol Sci. 2017;21(13):2981-8. [Google Scholar]
  33. An QD, Li YY, Zhang HX, Lu J, Yu XD, Lin Q, et al. Inhibition of bromodomain-containing protein 4 ameliorates oxidative stress-mediated apoptosis and cartilage matrix degeneration through activation of NF-E2-related factor 2-heme oxygenase-1 signaling in rat chondrocytes. Journal of cellular biochemistry. 2018. [Google Scholar]
  34. Hsu DZ, Chu PY, Wu PT, Shen PC, Jou IM. Oxidative stress participates in quadriceps muscle dysfunction during the initiation of osteoarthritis in rats. International journal of clinical and experimental pathology. 2015;8(10):12491-9. [Google Scholar]
  35. Elmas B, Yildiz T, Yazar H, Ilce Z, Bal C, Ozbek B, et al. New Oxidative Stress Markers Useful in the Diagnosis of Acute Appendicitis in Children: Thiol/Disulfide Homeostasis and the Asymmetric Dimethylarginine Level. Pediatric emergency care. 2017. [Google Scholar]
  36. Koc U, Tan S, Ertem AG, Gumus M, Ozbek B, Erel O. Evaluation of thiol-disulphide homeostasis in radiation workers. Int J Radiat Biol. 2017;93(7):705-10. [Google Scholar]
  37. Giri B, Dey S, Das T, Sarkar M, Banerjee J, Dash SK. Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018; 107:306-28. [Google Scholar]
Meta
Vol. 2 (4)
Download
Metric
History
Related

Volume 2 Issue 4

December 2018

All Articles
Copyright © 2012 - 2024 International Journal of Innovative Approaches in Science Research.
Pen Academic Publishing is a trademark of THDSoft.
This work is licensed under a Creative Commons Attribution 4.0 International License. CC BY-NC-ND
Electronic Journal Management System. This software was developed in Türkiye. ejournal.gen.tr
Pen Academic Publishing General Publication Policy: